Will Pretreatment of mixed healthy and cancer cells with Membranolytic Cyclic Polypeptides confer higher selectivity of ClO₂ (Chlorine Dioxide) towards cancer cells?

in chlorinedioxide •  8 days ago



    Lol, this image is ChatGPT generated, just for fun

    My conjecture

    Chlorine Dioxide (ClO₂) is dubbed the "ideal biocide" as its aqueous solution has been observed to exhibit high selective cytotoxicity towards microbes over human cells.
    The potential of ClO₂ as an anticancer agent has been investigated in several studies.

    Cancer cell membranes are known to be less rigid & more permeable. By administrating Membranolytic Polypeptides (which can be synthesized at much lower costs than sequence-specific peptides), the difference in membrane integrity between healthy and cancer cells can be increased, enhancing the selectivity of cancer drugs.

    Cyclic peptides are more resistant towards degradation by enzymes and chemical degradation by reactive radicals. Therefore, it will probably be more suitable to co-administer ClO₂ with Cyclic Membranolytic Polypeptides instead of linear ones.

    ChatGPT's Analysis:
    The likelihood that pretreatment with membranolytic cyclic polypeptides can confer higher selectivity of Chlorine Dioxide (ClO₂) toward cancer cells is moderate to high,


    Relevant Issues

    Q: Does any Cyclic (Poly)Peptides that increase cancer cells' membrane permeability while decreasing normal cells' membrane permeability exist?

    As of now, there are no widely known cyclic (poly)peptides that simultaneously increase cancer cell membrane permeability while decreasing normal cell membrane permeability. However, certain cyclic peptides have demonstrated selective activity toward cancer cells due to the distinct biochemical and biophysical properties of cancer cell membranes compared to normal cells.

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